Differences in the basal activity of the long terminal repeat determine different replicative capacities of two closely related human immunodeficiency virus type 1 isolates.

doi:10.1128/JVI.64.8.3654-3660.1990

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Article

Differences in the basal activity of the long terminal repeat determine different replicative capacities of two closely related human immunodeficiency virus type 1 isolates.

Journal of virology - 1 Aug 1990

Golub E I, Li G G, Volsky D J

Abstract excerpt

Two human immunodeficiency virus type 1 (HIV-1) variants derived from a single parental isolate were found to differ substantially in their ability to replicate in CD4-positive cells. Using transient chloramphenicol acetyltransferase expression assays, we show that the long terminal repeat (LTR) of the better-replicating virus has significantly higher capacity than that of the companion virus to direct gene...

Topics

Base Sequence
CD4 Antigens
Cell Line
Chloramphenicol O-Acetyltransferase
Cloning, Molecular
DNA, Viral
Genetic Variation
HIV-1
Humans
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Recombination, Genetic

Repetitive Sequences, Nucleic Acid

Restriction Mapping

T-Lymphocytes

Transcription, Genetic

Transfection

Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 2370677
DOI: 10.1128/JVI.64.8.3654-3660.1990
PMCID: PMC249658

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2370677-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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