Characterization of the herpes simplex virus type 1 strain 17+ neurovirulence gene RL1 and its expression in a bacterial system.

doi:10.1099/0022-1317-75-4-733

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Article

Characterization of the herpes simplex virus type 1 strain 17+ neurovirulence gene RL1 and its expression in a bacterial system.

The Journal of general virology - 1 Apr 1994

McKie E A, Hope R G, Brown S M, MacLean A R

Abstract excerpt

The DNA sequence of herpes simplex virus type 1 (HSV-1) strain 17+ in the region coding for the polypeptide ICP34.5 predicts a protein of 248 amino acids with a proposed M(r) of 26,158. The entire RL1 open reading frame was cloned into the expression vector pET8c to enable over-expression of ICP3...

Topics

Animals
Antibodies
Brain
DNA, Viral
Fluorescent Antibody Technique
Genes, Viral
Herpesvirus 1, Human
Lethal Dose 50
Mice
Mice, Inbred BALB C
Molecular Weight
Mutation
Viral Proteins
Virulence

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