Article
Structural heterogeneity in HLA-B70, a high-frequency antigen of black populations.
Tissue antigens - 1 Nov 1993
Domena J D, Little A M, Madrigal A J, Hildebrand W H, Johnston-Dow L, du Toit E, Bias W B, Parham P
Abstract excerpt
Although the B70 antigen exhibits allele frequencies of 8-23% in African and American black populations, it remains poorly defined. Cloning and sequencing of cDNA encoding B70 antigens from six cell lines has identified a group of three closely related alleles: B*1503, B*1509 and B*1510, that form a subgroup of the B15 family. The sequences of these alleles and, in particular, B*1503, are close to that of the...
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