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Article

Tight genetic linkage between the kdr insecticide resistance trait and a voltage-sensitive sodium channel gene in the house fly.

29 Mar 1994

Abstract excerpt

The kdr insecticide resistance trait in the house fly, Musca domestica, confers resistance to the rapid paralysis (knockdown) and lethal effects of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) and pyrethroids. Flies with the kdr trait exhibit reduced neuronal sensitivity to these compounds, which are known to act at voltage-sensitive sodium channels of nerve membranes. To test the hypothesis that a...

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PMID: 8146143
DOI: 10.1073/pnas.91.7.2483

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Tight genetic linkage between the kdr insecticide resistance trait and a voltage-sensitive sodium channel gene in the house fly.PMID 8146143Read ↗

Characterization of voltage-sensitive sodium channel gene coding sequences from insecticide-susceptible and knockdown-resistant house fly strains.Semantic proximity Read ↗

Identification of mutations in the housefly para-type sodium channel gene associated with knockdown resistance (kdr) to pyrethroid insecticides.Semantic proximity Read ↗

The molecular biology of knockdown resistance to pyrethroid insecticides.Semantic proximity Read ↗

Multiple origins of kdr-type resistance in the house fly, Musca domestica.Semantic proximity Read ↗

Sodium channel gene expression associated with pyrethroid resistant house flies and German cockroaches.Semantic proximity Read ↗

Knockdown resistance to DDT and pyrethroids in the house fly (Diptera: Muscidae): from genetic trait to molecular mechanism.Semantic proximity Read ↗

Point mutations in the Drosophila sodium channel gene para associated with resistance to DDT and pyrethroid insecticides.Semantic proximity Read ↗

Overcoming super-knock down resistance (super-kdr) mediated resistance: multi-halogenated benzyl pyrethroids are more toxic to super-kdr than kdr house flies.Semantic proximity Read ↗

The L1014F Point Mutation in the House Fly Vssc1 Sodium Channel Confers Knockdown Resistance to PyrethroidsSemantic proximity Read ↗

Diversity of knockdown resistance alleles in a single house fly population facilitates adaptation to pyrethroid insecticides.Semantic proximity Read ↗

Frequency of kdr gene in house fly field populations: correlation of pyrethroid resistance and kdr frequency.Semantic proximity Read ↗

Kdr allelic variation in pyrethroid resistant mosquitoes, Culex quinquefasciatus (S.).Semantic proximity Read ↗

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