Article
Membrane cofactor protein (CD46) of complement. Processing differences related to alternatively spliced cytoplasmic domains.
The Journal of biological chemistry - 8 Apr 1994
Liszewski M K, Tedja I, Atkinson J P
Abstract excerpt
Membrane cofactor protein (MCP, CD46), a widely distributed regulatory protein, inhibits complement activation on host cells and serves as a measles virus receptor. Most cells express four isoforms (with one of two cytoplasmic tails, CYT-1 or CYT-2). Previously, we noted that MCP precursors had v...
Topics
- Alternative Splicing
- Amino Acid Sequence
- Animals
- Antigens, CD
- CHO Cells
- Complement System Proteins
- Cricetinae
- Cytoplasm
- Electrophoresis, Gel, Pulsed-Field
- Membrane Cofactor Protein
- Membrane Glycoproteins
- Molecular Sequence Data
- Mutation
- Protein Processing, Post-Translational
- Recombinant Fusion Proteins