Article
Accelerated healing of duodenal ulcers by oral administration of a mutein of basic fibroblast growth factor in rats.
Gastroenterology - 1 Apr 1994
Szabo S, Folkman J, Vattay P, Morales R E, Pinkus G S, Kato K
Abstract excerpt
BACKGROUND/AIMS: Human basic fibroblast growth factor (bFGF) is an endothelial mitogen that stimulates angiogenesis and proliferation of other cells such as fibroblasts and smooth muscle cells. After this peptide was stabilized to acid and pepsin by site-specific mutagenesis, it was tested whether bFGF might accelerate the healing of experimental duodenal ulcers. METHODS: This mutein peptide (bFGF-CS23) was...
Topics
- Administration, Oral
- Animals
- Duodenal Ulcer
- Female
- Fibroblast Growth Factor 2
- Fibroblast Growth Factors
- Mutation
- Rats
- Rats, Sprague-Dawley
- Recombinant Proteins
- Wound Healing