Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Bifunctional transcriptional properties of YY1 in regulating muscle actin and c-myc gene expression during myogenesis.

Oncogene - 1 Apr 1994

Lee T C, Zhang Y, Schwartz R J

Abstract excerpt

Oncogene expression is generally incompatible with terminal cell differentiation as in myogenesis. We present evidence that this incompatibility can be caused in part by the dual activity of a Kruppel-related zinc finger, YY1 (formerly F-ACT1), in differentially regulating oncogene and muscle-specific gene expression. The c-myc and skeletal alpha-actin gene promoters contain YY1 binding sites thought to act...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Differentiation
Share to Cell Division
Share to Cells, Cultured

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA-Binding Proteins

Share to Gene Expression Regulation

Share to Mutation

Share to Repressor Proteins

Share to Transcription Factors

Source

Identifiers

PMID: 8134108

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bifunctional transcriptional properties of YY1 in regulating muscle actin and c-myc gene expression during myogenesis.PMID 8134108Read ↗

Nuclear Factor YY1 Inhibits Transforming Growth Factor β- and Bone Morphogenetic Protein-Induced Cell DifferentiationSemantic proximity Read ↗

Regulation of Yin Yang 1 by Tyrosine Phosphorylation.Semantic proximity Read ↗

JAZF1 promotes proliferation of C2C12 cells, but retards their myogenic differentiation through transcriptional repression of MEF2C and MRF4-Implications for the role of Jazf1 variants in oncogenesis and type 2 diabetes.Semantic proximity Read ↗

YEAF1/RYBP and YAF-2 are functionally distinct members of a cofactor family for the YY1 and E4TF1/hGABP transcription factors.Semantic proximity Read ↗

Multifunctional transcription factor YY1: a therapeutic target in human cancer?Semantic proximity Read ↗

YY1 as a regulator of replication-dependent hamster histone H3.2 promoter and an interactive partner of AP-2.Semantic proximity Read ↗

YY1 DNA binding and interaction with YAF2 is essential for Polycomb recruitment.Semantic proximity Read ↗

Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter.Semantic proximity Read ↗

Interaction between YY1 and the Retinoblastoma ProteinSemantic proximity Read ↗

Phenotypic differentiation without permanent cell-cycle arrest by skeletal myocytes with deregulated E2F-1.Semantic proximity Read ↗

Homeotic transformations of the axial skeleton of YY1 mutant mice and genetic interaction with the Polycomb group gene Ring1/Ring1A.Semantic proximity Read ↗

The Nuclear Factor YY1 Suppresses the Human Gamma Interferon Promoter through Two Mechanisms: Inhibition of AP1 Binding and Activation of a Silencer ElementSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.