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Article

Evidence for defects in membrane traffic in Paramecium secretory mutants unable to produce functional storage granules.

The Journal of cell biology - 1 Mar 1994

Gautier M C, Garreau de Loubresse N, Madeddu L, Sperling L

Abstract excerpt

The ciliated protozoan Paramecium has a regulated secretory system amenable to genetic analysis. The secretory storage granules, known as trichocysts, enclose a crystalline matrix with a genetically determined shape whose biogenesis involves proteolytic maturation of a family of precursor molecules into a heterogeneous set of small acidic polypeptides that crystallize within the maturing vesicles. We have...

Topics

Animals
Biological Transport
Cytoplasmic Granules
Golgi Apparatus
Membrane Proteins
Microscopy, Electron
Monensin
Mutation
Paramecium
Protein Precursors
Protein Processing, Post-Translational

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Protozoan Proteins

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Identifiers

PMID: 8132711
DOI: 10.1083/jcb.124.6.893
PMCID: PMC2119969

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8132711-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Evidence for defects in membrane traffic in Paramecium secretory mutants unable to produce functional storage granules.PMID 8132711Read ↗

Growth and form of secretory granules involves stepwise assembly but not differential sorting of a family of secretory proteins in Paramecium.Semantic proximity Read ↗

N-ethylmaleimide-sensitive factor is required to organize functional exocytotic microdomains in paramecium.Semantic proximity Read ↗

Small GTP-binding proteins associated with secretory vesicles of Paramecium.Semantic proximity Read ↗

Proteolytic processing of secretory proteins in Paramecium: immunological and biochemical characterization of the precursors of trichocyst matrix proteins.Semantic proximity Read ↗

Maturation of dense core granules in wild type and mutant Tetrahymena thermophila.Semantic proximity Read ↗

A Ca2+ influx associated with exocytosis is specifically abolished in a Paramecium exocytotic mutant.Semantic proximity Read ↗

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