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Article

Biochemical basis of warfarin and bromadiolone resistance in the house mouse, Mus musculus domesticus.

Biochemical pharmacology - 11 Feb 1994

Misenheimer T M, Lund M, Baker E M, Suttie J W

Abstract excerpt

Danish mice (Mus musculus domesticus) genetically resistant to the anticoagulant action of two 4-hydroxycoumarins, warfarin and bromadiolone, were examined to determine their mechanism of resistance. The hepatic vitamin K epoxide reductase in the bromadiolone-resistant mice and in one phenotype of warfarin-resistant mice was highly insensitive to in vitro inhibition by warfarin and bromadiolone. The kinetic...

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PMID: 8129744
DOI: 10.1016/0006-2952(94)90130-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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