Biochemical basis of warfarin and bromadiolone resistance in the house mouse, Mus musculus domesticus.

doi:10.1016/0006-2952(94)90130-9

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Article

Biochemical basis of warfarin and bromadiolone resistance in the house mouse, Mus musculus domesticus.

Biochemical pharmacology - 11 Feb 1994

Misenheimer T M, Lund M, Baker E M, Suttie J W

Abstract excerpt

Danish mice (Mus musculus domesticus) genetically resistant to the anticoagulant action of two 4-hydroxycoumarins, warfarin and bromadiolone, were examined to determine their mechanism of resistance. The hepatic vitamin K epoxide reductase in the bromadiolone-resistant mice and in one phenotype o...

Topics

4-Hydroxycoumarins
Animals
Dose-Response Relationship, Drug
Drug Resistance
Kinetics
Liver
Mice
Mixed Function Oxygenases
Phenotype
Rodenticides
Vitamin K Epoxide Reductases
Warfarin

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