Peroxisome proliferator and retinoid signaling pathways co-regulate preadipocyte phenotype and survival.

doi:10.1073/pnas.91.5.1786

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Article

Peroxisome proliferator and retinoid signaling pathways co-regulate preadipocyte phenotype and survival.

Proceedings of the National Academy of Sciences of the United States of America - 1 Mar 1994

Chawla A, Lazar M A

Abstract excerpt

Culture of mouse 3T3-L1 preadipocytes in medium containing delipidated bovine calf serum caused the cells to elongate and divide after reaching confluency. The continued proliferation correlated with sustained expression of the c-myc gene, which was repressed in control cells. Exposure of the cells to activators of peroxisome proliferator-activated receptor (PPAR), including clofibrate, WY-14,643, and...

Topics

3T3 Cells
5,8,11,14-Eicosatetraynoic Acid
Adipose Tissue
Animals
Apoptosis
Cell Survival
Clofibrate
Culture Media
Mice
Microbodies
Phenotype
Pyrimidines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Cytoplasmic and Nuclear

Receptors, Retinoic Acid

Retinoid X Receptors

Signal Transduction

Stem Cells

Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 8127882
DOI: 10.1073/pnas.91.5.1786
PMCID: PMC43248

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8127882-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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