Abiotrophic gene action in Homo sapiens: potential mechanisms and significance for the pathobiology of aging.

Abstract excerpt

A subset of genetic loci of Homo sapiens are reviewed that: 1) have the potential for allelic variation (either mutation or polymorphism) such that degenerative and/or proliferative phenotypic aberrations may be of relatively late onset ('abiotrophic'); 2) have phenotypic features which overlap, to some extent, with those of important age-related disorders of man (many of which are systematically tabulated in...

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