A cell biosensor specific for formaldehyde based on pH-sensitive transistors coupled to methylotrophic yeast cells with genetically adjusted metabolism.

doi:10.1006/abio.1993.1578

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Article

A cell biosensor specific for formaldehyde based on pH-sensitive transistors coupled to methylotrophic yeast cells with genetically adjusted metabolism.

Analytical biochemistry - 1 Dec 1993

Korpan Y I, Gonchar M V, Starodub N F, Shul'ga A A, Sibirny A A, El'skaya A V

Abstract excerpt

A cell biosensor specific for formaldehyde was developed using double-mutant cells of the methylotrophic yeast Hansenula polymorpha A3-11. The activities of some of the enzymes in the metabolic pathway of the wild-strain cells were deliberately suppressed by introducing respective genetic blocks...

Topics

Biosensing Techniques
Culture Media
Formaldehyde
Hot Temperature
Hydrogen-Ion Concentration
Kinetics
Mutation
Pichia
Transistors, Electronic

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