Pathophysiology of the pancreas in cystic fibrosis.

Abstract excerpt

Pancreatic insufficiency occurs in the majority of cystic fibrosis (CF) patients. Deficient fluid secretion is apparent at all levels of pancreatic function and leads to pancreatic protein hypersecretion which may in turn result in protein precipitation and ductal plugging. An impaired chloride and bicarbonate secretion appears to account for this fluid secretion deficit. A minority of CF patients have sufficient...

Topics

• Child
• Child, Preschool
• Cystic Fibrosis
• Exocrine Pancreatic Insufficiency
• Genotype
• Humans
• Infant
• Mutation
• Pancreas
• Phenotype