Article
Cystic fibrosis transmembrane conductance regulator (CFTR)-mediated residual chloride secretion does not protect against early chronic Pseudomonas aeruginosa infection in F508del homozygous cystic fibrosis patients.
Pediatric research - 1 Jan 2004
Derichs Nico, Mekus Frauke, Bronsveld Inez, Bijman Jan, Veeze Henk J, von der Hardt Horst, Tummler Burkhard, Ballmann Manfred
Abstract excerpt
Cystic fibrosis (CF) disease severity is characterized by a broad variability that has been attributed, in addition to the CF transmembrane conductance regulator (CFTR) genotype, to modulating factors such as CFTR-mediated residual chloride (Cl-) secretion. Moreover, CFTR has been suggested to function as a receptor for Pseudomonas aeruginosa (PA). In this study, we investigated whether or not the presence of...
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