Article
Characterization of Pseudomonas aeruginosa mutants that are deficient in exotoxin A synthesis and are altered in expression of regA, a positive regulator of exotoxin A.
Infection and immunity - 1 Mar 1994
West S E, Kaye S A, Hamood A N, Iglewski B H
Abstract excerpt
In Pseudomonas aeruginosa, production of exotoxin A, an ADP-ribosyltransferase, is a complex and highly regulated process. Two positively acting regulatory genes, regA and regB, have been cloned and characterized. To identify additional exotoxin A regulatory genes, we have characterized four N-methyl-N'-nitro-N-nitrosoguanidine-generated mutants of P. aeruginosa PA103 which are deficient in exotoxin A production....
Topics
- ADP Ribose Transferases
- Bacterial Toxins
- Base Sequence
- Exotoxins
- Genes, Bacterial
- Genetic Complementation Test
- Molecular Sequence Data
- Mutation
- Promoter Regions, Genetic
- Pseudomonas aeruginosa