Meiotic recombination in an Irish family with beta-thalassaemia.

doi:10.1007/BF00216141

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Article

Meiotic recombination in an Irish family with beta-thalassaemia.

Human genetics - 1 Aug 1993

Hall G W, Sampietro M, Barnetson R, Fitzgerald J, McCann S, Thein S L

Abstract excerpt

Using the technique of allele-specific priming of the polymerase chain reaction (PCR), the C-T substitution in codon 39 was identified as the cause of beta-thalassaemia in an Irish family. Analysis of the restriction fragment length polymorphisms (RFLPs) in the beta-globin gene cluster establishe...

Topics

Base Sequence
Codon
DNA
Female
Genetic Linkage
Globins
Haplotypes
Hematologic Tests
Humans
Male
Meiosis
Molecular Sequence Data
Multigene Family
Mutation
Pedigree
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Recombination, Genetic

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