Article
Meiotic recombination in an Irish family with beta-thalassaemia.
Human genetics - 1 Aug 1993
Hall G W, Sampietro M, Barnetson R, Fitzgerald J, McCann S, Thein S L
Abstract excerpt
Using the technique of allele-specific priming of the polymerase chain reaction (PCR), the C-T substitution in codon 39 was identified as the cause of beta-thalassaemia in an Irish family. Analysis of the restriction fragment length polymorphisms (RFLPs) in the beta-globin gene cluster established linkage of the beta-thalassaemia mutation to a particular beta-haplotype but indicated that a recombinational event...
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