Article
Mutations in human dynamin block an intermediate stage in coated vesicle formation.
The Journal of cell biology - 1 Aug 1993
van der Bliek A M, Redelmeier T E, Damke H, Tisdale E J, Meyerowitz E M, Schmid S L
Abstract excerpt
The role of human dynamin in receptor-mediated endocytosis was investigated by transient expression of GTP-binding domain mutants in mammalian cells. Using assays which detect intermediates in coated vesicle formation, the dynamin mutants were found to block endocytosis at a stage after the initi...
Topics
- Alternative Splicing
- Amino Acid Sequence
- Ca(2+) Mg(2+)-ATPase
- Dynamins
- Endocytosis
- Endoplasmic Reticulum
- Endosomes
- Fluorescent Antibody Technique
- Golgi Apparatus
- HeLa Cells
- Humans
- Molecular Sequence Data
- Mutation
- Transferrin