Polymorphism of human complement component C6: an amino acid substitution (Glu/Ala) within the second thrombospondin repeat differentiates between the two common allotypes C6 A and C6 B.

doi:10.1006/bbrc.1993.1841

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Article

Polymorphism of human complement component C6: an amino acid substitution (Glu/Ala) within the second thrombospondin repeat differentiates between the two common allotypes C6 A and C6 B.

Biochemical and biophysical research communications - 15 Jul 1993

Dewald G, Nöthen M M, Cichon S

Abstract excerpt

Component C6 of the human complement system exhibits a genetic polymorphism in all populations tested so far. Using isoelectric focusing two common allotypes, C6 A ('acidic') and C6 B ('basic') and a number of rare variants have been described. A comparison of the two published cDNA sequences of...

Topics

Alanine
Amino Acid Sequence
Base Sequence
Cell Adhesion Molecules
Cloning, Molecular
Complement C6
Genotype
Glutamates
Glutamic Acid
Humans
Isoelectric Focusing
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oligodeoxyribonucleotides

Platelet Membrane Glycoproteins

Point Mutation

Polymerase Chain Reaction

Polymorphism, Genetic

Polymorphism, Restriction Fragment Length

Source

Open in PubMed

Identifiers

PMID: 8101442
DOI: 10.1006/bbrc.1993.1841

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8101442-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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