Article
Human fibrinogen polymorphic site analysis by restriction endonuclease digestion and allele-specific polymerase chain reaction amplification: identification of polymorphisms at positions A alpha 312 and B beta 448.
Blood - 1 Oct 1993
Baumann R E, Henschen A H
Abstract excerpt
In the fibrinogen molecule, a total of seven sites have been tentatively identified as polymorphic; however, disagreements about these sites have been observed among the various protein and DNA sequence data published. To allow examination of the potential polymorphic sites at the DNA level, huma...
Topics
- Alleles
- Amino Acid Sequence
- Base Sequence
- DNA
- DNA Primers
- Deoxyribonucleases, Type II Site-Specific
- Female
- Fibrinogen
- Genotype
- Humans
- Male
- Molecular Sequence Data
- Pedigree
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Restriction Mapping