Unusual organization of the human T-cell receptor beta-chain gene complex is linked to recombination hotspots.

doi:10.1073/pnas.90.11.5026

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Article

Unusual organization of the human T-cell receptor beta-chain gene complex is linked to recombination hotspots.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jun 1993

Seboun E, Houghton L, Hatem C J, Lincoln R, Hauser S L

Abstract excerpt

Two rare Sfi I polymorphisms of 360 kb and 280 kb present within the human T-cell antigen receptor beta-chain gene complex were revealed by pulsed-field gel electrophoresis. They represent allelic variants of the polymorphic 330- and 300-kb Sfi I fragments previously described. The 360-kb polymor...

Topics

Chromosomes, Human, Pair 7
DNA
DNA Transposable Elements
Deoxyribonucleases, Type II Site-Specific
Genetic Variation
Humans
Linkage Disequilibrium
Lymphocytes
Multigene Family
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length
Receptors, Antigen, T-Cell, alpha-beta
Recombination, Genetic

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Identifiers

PMID: 8099448
DOI: 10.1073/pnas.90.11.5026
PMCID: PMC46646

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8099448-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Sequence Deletion