Article
Clonal studies of CD3- lymphoproliferative disease of granular lymphocytes.
Blood - 1 May 1993
Nash R, McSweeney P, Zambello R, Semenzato G, Loughran T P
Abstract excerpt
The lymphoproliferative disease of granular lymphocytes (LDGL) results from chronic proliferation of either CD3- or CD3+ large granular lymphocytes (LGLs). Most CD3+ LGLs have been well characterized as clonal LGL proliferations (LGL leukemia). In contrast, the clonal nature and clinical features of patients with CD3- LDGL have not been defined. In this study, we analyzed seven female patients with CD3- LDGL who...
Topics
- Adult
- Aged
- Alleles
- Base Sequence
- Blotting, Southern
- CD3 Complex
- DNA
- Deoxyribonucleases, Type II Site-Specific
- Female
- Genetic Linkage
- Humans
- Lymphocytes
