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Article

Dose-rate effects of neutrons and gamma-rays on the induction of mutation and oncogenic transformation in plateau-phase mouse m5S cells.

International journal of radiation biology - 1 Apr 1993

Komatsu K, Sawada S, Takeoka S, Kodama S, Okumura Y

Abstract excerpt

The dose-rate effect of 252-californium neutrons was investigated using confluent cultures of mouse m5S cells. The relative biological effectiveness (RBE) of neutrons for oncogenic transformation was increased from 3.3 to 5.1 when the dose-rate was reduced from 1.8 to 0.12 cGy/min. Similarly, neutron RBE values for HPRT- mutation were 4.9 and 7.4 at dose-rates of 1.8 and 0.12 cGy/min, respectively. The increases...

Topics

Animals
Californium
Cell Line
Cell Transformation, Neoplastic
Cesium Radioisotopes
Dose-Response Relationship, Radiation
Gamma Rays
Hypoxanthine Phosphoribosyltransferase
Mice
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neutrons

Relative Biological Effectiveness

Source

Identifiers

PMID: 8096859
DOI: 10.1080/09553009314550621

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8096859-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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