Article
Neutron radiation can activate K-ras via a point mutation in codon 146 and induces a different spectrum of ras mutations than does gamma radiation.
Molecular and cellular biology - 1 Jan 1990
Sloan S R, Newcomb E W, Pellicer A
Abstract excerpt
Neutron radiation is known to produce tumors in animals and cause cell transformation. We have developed a protocol to efficiently induce thymic lymphomas in RF/J mice by a single acute dose of neutron irradiation. Activated ras genes were detected in 17% (4 of 24) of the tumors analyzed. One of...
Topics
- Animals
- Base Sequence
- DNA
- Gamma Rays
- Gene Amplification
- Genes, ras
- Lymphoma
- Mice
- Mice, Nude
- Molecular Sequence Data
- Mutation
- Neoplasms, Radiation-Induced
- Neutrons
- Oncogene Protein p21(ras)
- Proto-Oncogenes