[The effectiveness of fractionated exposure of sarcoma M-1 to gamma-radiation and fast neutrons].

doi:10.7868/s0869803113020148

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Article

[The effectiveness of fractionated exposure of sarcoma M-1 to gamma-radiation and fast neutrons].

Radiatsionnaia biologiia, radioecologiia - 1 Jan 2000

Iuzhakov V V, Sevan'kaeva L E, Ul'ianenko S E, Iakovleva N D, Kuznetsova M N, Tsyganova M G, Fomina N K, Ingel' I E, Lychagin A A

Abstract excerpt

The effectiveness of fractionated exposure to gamma- and neutron radiation in their separate and combined use on the growth and functional morphology of mutant p53 sarcoma M-1 in rats was studied. Investigation techniques included immunostaining of PCNA and mutant p53 expressing cells, determination of mitotic activity and apoptotic death of tumor cells, as well as computer analysis of microscopic images. The...

Topics

Animals
Apoptosis
Dose Fractionation, Radiation
Fast Neutrons
Gamma Rays
Gene Expression Regulation, Neoplastic
Male
Mutation
Proliferating Cell Nuclear Antigen
Rats
Sarcoma
Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 24450208
DOI: 10.7868/s0869803113020148

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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