Article
Characterization of a new allele of the human ERBB2 gene by allele-specific competition hybridization.
Genomics - 1 Feb 1993
Ehsani A, Low J, Wallace R B, Wu A M
Abstract excerpt
Nucleotide sequence analysis of the ERBB2 proton-oncogene in human breast tumors revealed a sequence variation at codons 654 and 655, corresponding to the transmembrane region of the protein. To investigate this polymorphism, genotyping of 340 unrelated individuals was conducted by allele-specific oligonucleotide (ASO) hybridization of DNA amplified from the ERBB2 transmembrane region. ASO hybridization under...
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