Characterization of a new allele of the human ERBB2 gene by allele-specific competition hybridization.

doi:10.1006/geno.1993.1081

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Article

Characterization of a new allele of the human ERBB2 gene by allele-specific competition hybridization.

Genomics - 1 Feb 1993

Ehsani A, Low J, Wallace R B, Wu A M

Abstract excerpt

Nucleotide sequence analysis of the ERBB2 proton-oncogene in human breast tumors revealed a sequence variation at codons 654 and 655, corresponding to the transmembrane region of the protein. To investigate this polymorphism, genotyping of 340 unrelated individuals was conducted by allele-specifi...

Topics

Alleles
Amino Acid Sequence
Base Sequence
Breast Neoplasms
DNA, Neoplasm
Genetic Predisposition to Disease
Humans
Lymphoproliferative Disorders
Molecular Sequence Data
Nucleic Acid Hybridization
Proto-Oncogene Proteins
Proto-Oncogenes
Receptor, ErbB-2

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