Article
Tumor necrosis factor alpha polymorphism correlates with deleterious effects of ultraviolet B light on cutaneous immunity.
Cancer research - 15 Feb 1993
Vincek V, Kurimoto I, Medema J P, Prieto E, Streilein J W
Abstract excerpt
Intradermally injected tumor necrosis factor alpha (TNF-alpha) mimics the effects of UV B light (UVB) radiation and neutralizing anti-TNF-alpha antibodies abolish the deleterious effects of UVB on induction of contact hypersensitivity suggesting that TNF-alpha is the major mediator of UVB effects...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Chromosome Mapping
- Dermatitis, Contact
- Dinitrofluorobenzene
- Exons
- Injections, Intradermal
- Introns
- Mice
- Mice, Inbred Strains
- Molecular Sequence Data
- Phenotype
- Polymorphism, Genetic
- Polymorphism, Restriction Fragment Length
- Skin
- Species Specificity
- Tumor Necrosis Factor-alpha