Article
N-methyl-D-aspartate receptor antagonist and dopamine D1 and D2 agonist interactions in 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine-induced hemiparkinsonian monkeys.
The Journal of pharmacology and experimental therapeutics - 1 Jan 1993
Domino E F, Sheng J
Abstract excerpt
The noncompetitive N-methyl-D-aspartate antagonist (5R,10S)-(+)-5-methyl- 10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate (MK-801) and three dopamine agonists [(+/-)6-chloro-7,8-dihydroxy-2,3,4,5-tetrahydro-1-phenyl-1H-3-benzazepin e hydrobromide (SKF-81297), (+/-)6,chloro-7,...
Topics
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
- Animals
- Behavior, Animal
- Disease Models, Animal
- Dizocilpine Maleate
- Dopamine Agents
- Dose-Response Relationship, Drug
- Drug Interactions
- Female
- Genetic Variation
- Locomotion
- Macaca nemestrina
- Motor Activity
- Parkinson Disease, Secondary
- Receptors, Dopamine D1
- Receptors, Dopamine D2
- Receptors, N-Methyl-D-Aspartate