Article
Influence of non-inherited maternal HLA antigens on occurrence of rheumatoid arthritis.
Lancet (London, England) - 23 Jan 1993
ten Wolde S, Breedveld F C, de Vries R R, D'Amaro J, Rubenstein P, Schreuder G M, Claas F H, van Rood J J
Abstract excerpt
Many HLA-associated diseases occur in patients not carrying the putative predisposing antigen. The suggestion that this might be due to disease heterogeneity is not sufficiently supported by available data. We hypothesise that HLA-DR4-associated genetic susceptibility to rheumatoid arthritis is due to an effect of DR4 on T-cell receptor repertoire expression and that the presence of antigen in the mother is...
Topics
- Arthritis, Rheumatoid
- Evaluation Studies as Topic
- Gene Expression
- Gene Frequency
- HLA-DR1 Antigen
- HLA-DR3 Antigen
- HLA-DR4 Antigen
- Histocompatibility Testing
- Humans
- Netherlands
- Pedigree