Article
Methylation- and mutation-dependent stimulation of Alu transcription in vitro.
Biochemical and biophysical research communications - 15 Sept 1994
Vorce R L, Lee B, Howard B H
Abstract excerpt
Alu genes are GC-rich, highly repetitive genetic elements whose functions remain unknown. Members of this family are readily transcribed in vitro by RNA polymerase III, but RNA corresponding to only a small sub-set of Alu elements has been found in vivo. Based on the hypothesis that methylation of Alu elements affects their transcription, the transcriptional activity of unmethylated and methylated template DNA...
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