Methylation- and mutation-dependent stimulation of Alu transcription in vitro.

doi:10.1006/bbrc.1994.2260

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Article

Methylation- and mutation-dependent stimulation of Alu transcription in vitro.

Biochemical and biophysical research communications - 15 Sept 1994

Vorce R L, Lee B, Howard B H

Abstract excerpt

Alu genes are GC-rich, highly repetitive genetic elements whose functions remain unknown. Members of this family are readily transcribed in vitro by RNA polymerase III, but RNA corresponding to only a small sub-set of Alu elements has been found in vivo. Based on the hypothesis that methylation o...

Topics

Base Sequence
Binding Sites
DNA
DNA-Cytosine Methylases
Methylation
Molecular Sequence Data
Mutagenesis, Site-Directed
Mutation
RNA Polymerase III
Repetitive Sequences, Nucleic Acid
Templates, Genetic
Transcription, Genetic

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