Alu RNA transcripts in human embryonal carcinoma cells. Model of post-transcriptional selection of master sequences.

doi:10.1016/0022-2836(92)90626-u

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Alu RNA transcripts in human embryonal carcinoma cells. Model of post-transcriptional selection of master sequences.

Journal of molecular biology - 5 Aug 1992

Sinnett D, Richer C, Deragon J M, Labuda D

Abstract excerpt

Alu master sequences colonized the human genome using RNA as amplification intermediate. To understand this phenomenon better we isolated and analyzed Alu RNA from NTera2D1 pluripotential cells. Northern hybridization, primer extension, cDNA cloning and sequencing data are congruent and demonstrate a low level of Alu specific transcription. These bona fide RNA Polymerase III Alu transcripts, although enriched in...

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