Article
Molecular basis of beta-thalassemia in Japan: heterogeneity and origins of mutations.
Acta haematologica - 1 Jan 1994
Wakamatsu C, Ichinose M, Manabe J, Fucharoen S, Sawada H, Ohga S, Nishimura J, Nukina H, Harada T, Shirahata S
Abstract excerpt
Characterization of beta-thalassemia mutations was attempted for 13 unrelated Japanese patients heterozygous for beta-thalassemia. We have systematically analyzed beta-thalassemia genes using polymerase-chain-reaction-related techniques; dot blot hybridization with oligonucleotide probes compleme...
Topics
- Adolescent
- Adult
- Amino Acid Sequence
- Base Sequence
- Child
- Child, Preschool
- Codon
- Female
- Genetic Variation
- Haplotypes
- Humans
- Immunoblotting
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Nucleic Acid Hybridization
- Restriction Mapping