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Article

Mitogen-activated protein kinases mediate changes in gene expression, but not cytoskeletal organization associated with cardiac muscle cell hypertrophy.

The Journal of cell biology - 1 Sept 1994

Thorburn J, Frost J A, Thorburn A

Abstract excerpt

Shortly after birth, cardiac myocytes lose the ability to divide, and, in adult animals, heart muscle grows by a process of cellular hypertrophy where each individual cell gets larger. We have previously shown that activated Ras protein can induce markers of the hypertrophic phenotype, including atrial natriuretic factor (ANF) expression and organization of contractile proteins, and that Ras is at least partially...

Topics

Actins
Animals
Calcium-Calmodulin-Dependent Protein Kinases
Cells, Cultured
Cytoskeleton
Enzyme Activation
Gene Expression Regulation
Hypertrophy
Mitogen-Activated Protein Kinase 1
Mitogen-Activated Protein Kinase 3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mitogen-Activated Protein Kinases

Mitogens

Mutation

Myocardium

Phenotype

Phenylephrine

Rats

Tetradecanoylphorbol Acetate

Source

Open in PubMed Open full text

Identifiers

PMID: 8089186
DOI: 10.1083/jcb.126.6.1565
PMCID: PMC2290965

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8089186-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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