Article
Myosin light chain kinase mediates sarcomere organization during cardiac hypertrophy in vitro.
Nature medicine - 1 Feb 2000
Aoki H, Sadoshima J, Izumo S
Abstract excerpt
During the development of hypertrophy, cardiac myocytes increase organization of the sarcomere, a highly ordered contractile unit in striated muscle cells. Several hypertrophic agonists, such as angiotensin II, phenylephrine, and endothelin-1, have been shown to promote the sarcomere organization. However, the signaling pathway, which links extracellular stimuli to sarcomere organization, has not been clearly...
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