Article
Amino acids Lys-Asp-Asp-Lys-Pro-Val402 in the Ca(2+)-ATPase of cardiac sarcoplasmic reticulum are critical for functional association with phospholamban.
The Journal of biological chemistry - 16 Sept 1994
Toyofuku T, Kurzydlowski K, Tada M, MacLennan D H
Abstract excerpt
Phospholamban interacts with SERCA2 (sarco/endoplasmic reticulum calcium ATPase isoform 2) but not SERCA3. The use of chimeric SERCA2/SERCA3 molecules has revealed that amino acids 336-412 in the phosphorylation domain of SERCA2 are essential for functional association with phospholamban (Toyofuk...
Topics
- Amino Acid Sequence
- Animals
- Binding Sites
- Calcium-Binding Proteins
- Calcium-Transporting ATPases
- Molecular Sequence Data
- Mutation
- Myocardium
- Peptide Fragments
- Rabbits
- Recombinant Fusion Proteins
- Sarcoplasmic Reticulum