Embryonic kidney rudiments grown in adult mice fail to mimic the Wilms' phenotype, but show strain-specific morphogenesis.

Abstract excerpt

12.5- to 14.5-day mouse embryonic kidney fragments were grown syngeneically under kidney or testis capsules in 3 mouse strains for 5-26 weeks to reproduce the Wilms' tumour (WT) phenotype previously reported. About 65% of the transplants grew, but none showed true WT morphology, invaded local tissue or developed metastases. In Swiss mice, most growths contained disorganized stromal and blast cells, but also had...

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