Article
Genetic mechanism of leukemia predisposition in a family with 7 cases of acute myeloid leukemia.
Cancer genetics and cytogenetics - 1 Aug 1994
He L Z, Lu L H, Chen Z Z
Abstract excerpt
This paper describes a family in which seven members, involving three consecutive generations, suffered from acute myeloid leukemia during the past 16 years. The genetic abnormalities were vertically transmitted in a Mendelian dominant manner without sex linkage. Cytogenetic approaches, such as G-banding karyotypes, micronuclei (MN), chromosome aberrations (CA), fragile sites (Fra), cell cycle time (Tc), sister...
Topics
- Acute Disease
- Adult
- Cell Division
- Child
- Child, Preschool
- Chromosome Aberrations
- Chromosome Fragile Sites
- Chromosome Fragility
- Female
- Genetic Predisposition to Disease
- Humans