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Article

Meiotic origin of trisomy in neoplasms: evidence in a case of erythroleukaemia.

Leukemia - 1 Jun 2001

Minelli A, Morerio C, Maserati E, Olivieri C, Panarello C, Bonvini L, Leszl A, Rosanda C, Lanino E, Danesino C, Pasquali F

Abstract excerpt

Trisomic cells in neoplasms may represent abnormal clones originated from a tissue-confined mosaicism, and arise therefore by a meiotic error. We report on a 16-month-old child with erythroleukaemia (AML-M6), whose marrow karyotype at onset was 48,XX,del(13)(q12q14),del(14)(q22q32),+21,+21. The parental origin of the supernumerary chromosomes 21 was investigated by comparing 10 polymorphic loci scattered along...

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PMID: 11417485
DOI: 10.1038/sj.leu.2402123

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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