Article
Detection of C-myb genetic alterations and mutant p53 serum protein in patients with benign and malignant colon lesions.
Anticancer research - 1 Jan 2000
Greco C, Gandolfo G M, Mattei F, Gradilone A, Alvino S, Pastore L I, Casale V, Casole P, Grassi A, Cianciulli A M
Abstract excerpt
C-myb structural alterations were analysed by Southern blot hybridization in 55 adenomatous polyps and 21 adenocarcinomas of the colon. Gene amplification was observed in 8 cases (14.5%) and c-myb rearrangements in 3 cases (5.4%) of the preneoplastic lesions analysed. A higher percentage of c-myb abnormalities (23.8%) was shown by malignant tumors. As far as mutant p53 protein is concerned, it was detected both...
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