Attenuated hypercholesterolemic response to a high-cholesterol diet in subjects heterozygous for the apolipoprotein A-IV-2 allele.

Abstract excerpt

BACKGROUND: Previous studies have suggested that the variant apolipoprotein (apo) allele apo A-IV-2 may influence the response of the plasma cholesterol concentration to dietary cholesterol. METHODS: We measured plasma lipids and lipoproteins in 11 subjects who were heterozygous for the apo A-IV-2 allele (apo A-IV-1/2 heterozygotes) and a control group of 12 subjects who were homozygous for the common apo A-IV...

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