In Vivo Selection of Reduced Susceptibility to Carbapenems in <i>Acinetobacter baumannii</i> Related to IS <i>Aba1</i> -Mediated Overexpression of the Natural <i>bla</i> _OXA-66 Oxacillinase Gene

Abstract excerpt

Two clonally related Acinetobacter baumannii isolates, A1 and A2, were obtained from the same patient. Isolate A2, selected after an imipenem-containing treatment, showed reduced susceptibility to carbapenems. This resistance pattern was related to insertion of the ISAba1 element upstream of the naturally occurring bla(OXA-66) carbapenemase gene as demonstrated by sequencing, reverse transcription-PCR analysis,...

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