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Article

A functional polymorphism of the TNF-alpha gene that is associated with type 2 DM.

Biochemical and biophysical research communications - 9 May 2008

Susa Shinji, Daimon Makoto, Sakabe Jun-Ichi, Sato Hidenori, Oizumi Toshihide, Karasawa Shigeru, Wada Kiriko, Jimbu Yumi, Kameda Wataru, Emi Mitsuru, Muramatsu Masaaki, Kato Takeo

Abstract excerpt

To examine the association of the tumor necrosis factor-alpha (TNF-alpha) gene region with type 2 diabetes (DM), 11 single-nucleotide polymorphisms (SNPs) of the region were analyzed. The initial study using a sample set (148 cases vs. 227 controls) showed a significant association of the SNP IVS1G+123A of the TNF-alpha gene with DM (p=0.0056). Multiple logistic regression analysis using an enlarged sample set...

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PMID: 18328809
DOI: 10.1016/j.bbrc.2008.02.121

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TNF

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