Article
The Legionella pneumophila major secretory protein, a protease, is not required for intracellular growth or cell killing.
Infection and immunity - 1 Aug 1990
Szeto L, Shuman H A
Abstract excerpt
The Legionella pneumophila major secretory protein (Msp) is a Zn2+ metalloprotease whose function in pathogenesis is unknown. The structural gene for the Msp protease, mspA, was isolated from an L. pneumophila genomic library. In Escherichia coli which contain plasmids with the mspA gene, Msp pro...
Topics
- Bacterial Proteins
- Blotting, Southern
- Cell Fractionation
- Cell Survival
- Cells, Cultured
- DNA Transposable Elements
- Electrophoresis, Polyacrylamide Gel
- Escherichia coli
- Gene Library
- Genes, Bacterial
- Humans
- Legionella
- Macrophages
- Metalloendopeptidases
- Mutation
- Phenotype
- Plasmids