Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A comparison of Southern blot and polymerase chain reaction as techniques to identify loss of DNA heterozygosity in colorectal cancer.

The Australian and New Zealand journal of surgery - 1 Aug 1994

Hewett P J, Firgaira F, Morley A

Abstract excerpt

Alterations in the tumour suppressor gene p53 have been found in a wide variety of tumours. The variable number tandem repeat present at the YNZ22 locus is a highly polymorphic marker closely linked to the p53 gene. Examination for loss of heterozygosity at the YNZ22 locus has been carried out by Southern blot or polymerase chain reaction (PCR). A comparison of these techniques shows a 100% concordance rate in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Blotting, Southern
Share to Gene Deletion

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, p53

Share to Heterozygote

Share to Polymerase Chain Reaction

Share to Polymorphism, Genetic

Share to Repetitive Sequences, Nucleic Acid

Source

Identifiers

PMID: 8048895
DOI: 10.1111/j.1445-2197.1994.tb02285.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

A comparison of Southern blot and polymerase chain reaction as techniques to identify loss of DNA heterozygosity in colorectal cancer.PMID 8048895Read ↗

Constant denaturant gel electrophoresis as a rapid screening technique for p53 mutations.Semantic proximity Read ↗

Polymerase chain reaction-based approaches for detection of allelic loss in the p53 tumor suppressor gene in colon neoplasms.Semantic proximity Read ↗

Human breast cancer: frequent p53 allele loss and protein overexpression.Semantic proximity Read ↗

Allelic imbalance at chromosome 17p13.3 (YNZ22) in breast cancer is independent of p53 mutation or p53 overexpression and is associated with poor prognosis at medium-term follow-up.Semantic proximity Read ↗

Association of p53 gene and protein alterations with metastases in colorectal cancer.Semantic proximity Read ↗

Loss of heterozygosity of nucleotide excision repair factors in sporadic ovarian, colon and lung carcinomas: implication for their roles of carcinogenesis in human solid tumorsSemantic proximity Read ↗

Validation of a targeted next-generation sequencing approach to detect mismatch repair deficiency in colorectal adenocarcinomaSemantic proximity Read ↗

Identification of tumour-associated and germ line p53 mutations in canine mammary cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.