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Article

A comparison of Southern blot and polymerase chain reaction as techniques to identify loss of DNA heterozygosity in colorectal cancer.

The Australian and New Zealand journal of surgery - 1 Aug 1994

Hewett P J, Firgaira F, Morley A

Abstract excerpt

Alterations in the tumour suppressor gene p53 have been found in a wide variety of tumours. The variable number tandem repeat present at the YNZ22 locus is a highly polymorphic marker closely linked to the p53 gene. Examination for loss of heterozygosity at the YNZ22 locus has been carried out by...

Topics

Alleles
Blotting, Southern
Chromosomes, Human, Pair 17
Colonic Neoplasms
DNA, Neoplasm
Gene Deletion
Genes, p53
Heterozygote
Humans
Polymerase Chain Reaction
Polymorphism, Genetic
Rectal Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Repetitive Sequences, Nucleic Acid

Source

Identifiers

PMID: 8048895
DOI: 10.1111/j.1445-2197.1994.tb02285.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8048895-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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