Article
Plasma level and gene polymorphism of angiotensin-converting enzyme in relation to myocardial infarction.
Circulation - 1 Aug 1994
Cambien F, Costerousse O, Tiret L, Poirier O, Lecerf L, Gonzales M F, Evans A, Arveiler D, Cambou J P, Luc G
Abstract excerpt
BACKGROUND: The angiotensin-converting enzyme (ACE) plays an important role in the production of angiotensin II and the degradation of bradykinin, two peptides involved in cardiovascular homeostasy. Presence of a polymorphism in the ACE gene (ACE Ss) has been postulated from segregation analysis of plasma ACE in families. This putative polymorphism, which strongly affects the plasma and cellular levels of ACE,...
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