Article
Genetics of angiotensin I-converting enzyme.
Clinical and experimental hypertension (New York, N.Y. : 1993) - 1 Jan 2000
Costerousse O, Danilov S, Alhenc-Gelas F
Abstract excerpt
The ACE gene is constitutively expressed in several types of somatic cells, including vascular cells. A soluble form of the enzyme is secreted in plasma by proteolytic cleavage of the membrane anchor. The interindividual variability in plasma ACE levels is very large, and a family study has indicated that it was under the influence of a major gene polymorphism. An insertion (I) deletion (D) polymorphism in intron...
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