Article
Molecular and clinical correlations in spinocerebellar ataxia type I: evidence for familial effects on the age at onset.
American journal of human genetics - 1 Aug 1994
Ranum L P, Chung M Y, Banfi S, Bryer A, Schut L J, Ramesar R, Duvick L A, McCall A, Subramony S H, Goldfarb L
Abstract excerpt
The spinocerebellar ataxias are a group of debilitating neurodegenerative diseases for which a clinical classification system has proved unreliable. We have recently isolated the gene for spinocerebellar ataxia type 1 (SCA1) and have shown that the disease is caused by an expanded, unstable, CAG...
Topics
- Adolescent
- Age of Onset
- Base Sequence
- Child
- Chromosomes, Human, Pair 6
- DNA
- DNA Primers
- Family Health
- Female
- Gene Expression
- Genes, Dominant
- Humans
- Linear Models
- Male
- Middle Aged
- Molecular Sequence Data