Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Age at onset variance analysis in spinocerebellar ataxias: A study in a Dutch–French cohort

3 Mar 2005

Abstract excerpt

In dominant spinocerebellar ataxias (SCAs), the issue of whether non-CAG dependent factors contribute to onset age remains unsettled. Data on SCA genotype, onset age, normal/expanded CAG repeat length, sex of the patient and transmitting parent, and family details were available from 802 patients. Based on the model [log(10) (age at onset) = k - b CAG(exp) + epsilon], we examined changes in adjusted R(2) and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Neurodegenerative Diseases
Share to Mitochondrial Function and Pathology
Share to Neurological disorders and treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15747371
DOI: 10.1002/ana.20424

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Age at onset variance analysis in spinocerebellar ataxias: A study in a Dutch–French cohortPMID 15747371Read ↗

Prediction of the age at onset in spinocerebellar ataxia type 1, 2, 3 and 6.Semantic proximity Read ↗

Spinocerebellar ataxias in the Netherlands: prevalence and age at onset variance analysis.Semantic proximity Read ↗

Genetic analysis of age at onset variation in spinocerebellar ataxia type 2Semantic proximity Read ↗

Spinocerebellar ataxia type 2: polyQ repeat variation in the CACNA1A calcium channel modifies age of onset.Semantic proximity Read ↗

Molecular and clinical correlations in spinocerebellar ataxia type I: evidence for familial effects on the age at onset.Semantic proximity Read ↗

Biological and clinical characteristics of individuals at risk for spinocerebellar ataxia types 1, 2, 3, and 6 in the longitudinal RISCA study: analysis of baseline data.Semantic proximity Read ↗

Age is an important independent modifier of SCA3 phenotype severity.Semantic proximity Read ↗

Determinants of onset age in Friedreich's ataxia.Semantic proximity Read ↗

Determinants of age at onset in a Portuguese cohort of autosomal dominant spastic paraplegia.Semantic proximity Read ↗

Phenotype variability and early onset ataxia symptoms in spinocerebellar ataxia type 7: comparison and correlation with other spinocerebellar ataxias.Semantic proximity Read ↗

SNCA: major genetic modifier of age at onset of Parkinson's disease.Semantic proximity Read ↗

Redefining the Pathogenic CAG Repeat Units Threshold in CACNA1A for Spinocerebellar Ataxia Type 6Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.