Analysis of spinocerebellar ataxia type 1 (SCA1)-related CAG trinucleotide expansion in Japan.

doi:10.1212/wnl.45.8.1587

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Article

Analysis of spinocerebellar ataxia type 1 (SCA1)-related CAG trinucleotide expansion in Japan.

Neurology - 1 Aug 1995

Kameya T, Abe K, Aoki M, Sahara M, Tobita M, Konno H, Itoyama Y

Abstract excerpt

Spinocerebellar ataxia type 1 (SCA1) is a neurodegenerative disorder caused by expansion of a CAG trinucleotide repeat. We analyzed CAG repeat expansion in 25 families in the northeast of Japan with hereditary ataxia of Menzel type. Twenty of 38 patients in 12 families had expanded allele for SCA...

Topics

Adult
Alleles
Central Nervous System
DNA
Female
Humans
Japan
Male
Middle Aged
Muscles
Mutation
Phenotype
RNA
RNA, Messenger
Repetitive Sequences, Nucleic Acid
Spinocerebellar Degenerations

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