Temporal correlation between a single amino acid change in the VP4 of a porcine rotavirus and a marked change in pathogenicity.

doi:10.1006/viro.1994.1397

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Article

Temporal correlation between a single amino acid change in the VP4 of a porcine rotavirus and a marked change in pathogenicity.

Virology - 1 Aug 1994

Burke B, Bridger J C, Desselberger U

Abstract excerpt

We previously described a marked increase in the pathogenicity of a cell culture grown porcine rotavirus, PRV 4F, during serial passage in gnotobiotic piglets (Bridger et al., 1992). Here we report close temporal correlation between this change in pathogenicity and an amino acid change within a h...

Topics

Amino Acid Sequence
Animals
Base Sequence
Capsid
Capsid Proteins
DNA Primers
Molecular Sequence Data
Mutation
Rotavirus
Rotavirus Infections
Sequence Alignment
Sequence Homology, Amino Acid
Solubility
Swine
Swine Diseases

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