Article
Impairment of ligand binding and growth signaling of mutant IL-2 receptor gamma-chains in patients with X-linked severe combined immunodeficiency.
Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 1994
Ishii N, Asao H, Kimura Y, Takeshita T, Nakamura M, Tsuchiya S, Konno T, Maeda M, Uchiyama T, Sugamura K
Abstract excerpt
The IL-2R gamma-chain is an indispensable subunit for the functional IL-2R. Recently, mutations of the gamma-chain have been reported to be closely associated with X-linked severe combined immunodeficiency (XSCID). The present study reveals that three patients with XSCID have three different muta...
Topics
- Base Sequence
- Cell Division
- Cell Line
- DNA Primers
- Gene Expression
- Genes, fos
- Genes, jun
- Genes, myc
- Humans
- Ligands
- Male
- Molecular Sequence Data
- Mutation
- RNA, Messenger
- Receptors, Interleukin-2